Biotin Update - June 2022

More and more reasearch is being published on MS and related neurological condidtions. As the drive to better understand the link between the immune and neurological systems, including the brain. As this progression gathers speed, the gained knowlege is having a marked effect on slowing the progression of MS.

Over the past few years 20-30 papers have been published on neurological research relating to MS. A number of these relating to Biotin and its role in the brain and central nervous system (CNS).

Neuroparthic pain, the burning and tinglingin the extremities, is one of the most trying or tiresome symptoms of MS. A 2021 study[1] has shown that Biotin can have a marked impact on this pain, reducing the need for analgesic drugs. The effect of 4, 8 and 16mg/kg of live body weight were evaluated. For a 60kg person these doses are equivalent to 240mg - 640mg per day. All doses demonstrated similar results, indicated lower a lower dose was as effective as a higher dose.

Another study published in 2020[2] identifies Biotin as a potential therapy for neuroprotection.

Yet another research article[3] also published in 2020 follows up on the work done by MedDay. Identifying HD Biotin as having the effect on increasing ATP (energy) levels and reversing axonal damage. 

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    1. Ali-Reza Abed. et all. Effect of biotin supplementation on neuropathic pain induced by chronic constriction of the sciatic nerve in the rat. Research in Pharmaceutical Sciences, June 2021; 16(3): 250-259
    2. Kelly H Lohr, et al. Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model. 3360833618 | PNAS | December 29, 2020 | vol. 117 | no. 52
    3. Stephane Forecade et all. HDB restores redox balance,energy lipid homeostasis, and axonal health in a model of adrenoleucodystrophy. Brain Pathology 30 [2020] 945-963.